LGG-21. FGFR1 GENE MUTATION AS A POTENTIAL RISK FACTOR FOR SPONTANEOUS INTRACRANIAL HEMORRHAGE IN PEDIATRIC LOW GRADE GLIOMA PATIENTS

Abstract The Fibroblast Growth Factor Receptor 1 (FGFR1) gene is the second most altered in pediatric LGGs and has been associated with poorer prognoses. A recent study suggested a link between FGFR1 mutation spontaneous intracranial hemorrhage LGG patients, an event that can be detrimental to cognitive development and, some cases, even fatal. current aimed further confirm this by following 49 patients treated at Arnold Palmer Hospital for Children from 2007-2022 investigating occurrences of hemorrhage. We accessed their treatment course, clinical outcome, radiographic findings, pathological findings. Genetic analysis was performed as part standard care time tumor resection or biopsy. Of forty-nine we followed, eight (16.3%) experienced Five these (62.5%) had mutation. Out only six them mutation, five out (83.3%) point during treatment. one patient did not experience lacked classic presented variant unknown significance yet regarded pathogenic. These findings are consistent aforementioned significant because, date, little known about tumor-specific risk factors hemorrhages. Understanding could help clinicians better predict potentially prevent devastating effects.